Background Natural plant-based cosmetics have gained increasing attention due to their safety, biocompatibility, and high antioxidant potential. Rosa damascena is a well-known medicinal and aromatic plant widely used in traditional Syrian medicine for its skin-soothing, anti-inflammatory, and antioxidant properties. The incorporation of Ascorbic acid enhances collagen synthesis, reduces oxidative stress, and improves skin brightness. Recent advances in nanotechnology, particularly the use of Silver nanoparticles, have enabled improved delivery and stability of bioactive compounds in dermatological formulations. Objective This study aims to develop an innovative nano-extract serum based on Rosa damascena and vitamin C using a green synthesis method involving silver nanoparticles, and to evaluate its potential as a functional cosmetic product with antioxidant and skin-enhancing properties. Methods Nano-Phase Preparation Silver nanoparticles (AgNPs) were synthesized using silver nitrate (AgNO₃) and Beta-glucan as a natural stabilizing and reducing agent: Beta-glucan was heated to 140°C to convert its triple helix structure into single polymer chains AgNO₃ was added to the system without external chemical reducing agents Damask rose extract was incorporated into the reaction mixture The solution was heated to 90°C for 5 minutes to facilitate nanoparticle formation Serum Formulation 90 mL of nano-extract (rose + AgNPs) 10 mL of vitamin C solution 5 mL glycerin as a moisturizing agent Addition of suitable preservatives The mixture was homogenized in a lukewarm water bath until a stable serum was obtained. Results The developed nano-serum demonstrated: Successful formation of silver nanoparticles via green synthesis High content of phenolic compounds derived from Rosa damascena Enhanced antioxidant potential due to the synergistic effect of phenolics and vitamin C Improved formulation stability and homogeneity The presence of AgNPs is expected to enhance: Skin penetration and bioavailability of active compounds Antimicrobial activity Preservation efficiency Discussion The integration of nanotechnology with traditional herbal formulations represents a significant advancement in cosmetic science. The use of beta-glucan as a natural reducing agent aligns with green chemistry principles, eliminating the need for toxic chemical reagents. The synergistic combination of Rosa damascena and vitamin C enhances antioxidant defense mechanisms, potentially reducing oxidative skin damage and supporting collagen synthesis. Additionally, silver nanoparticles may contribute to antimicrobial protection and improved delivery of active ingredients. This formulation reflects a novel approach to transforming traditional botanical knowledge into modern, high-performance dermocosmetic products. Conclusion The developed nano-extract serum represents an innovative, eco-friendly cosmetic formulation combining natural antioxidants with nanotechnology. The method provides: Higher chemical functionality Enhanced bioavailability Improved formulation stability This approach offers strong potential for applications in skincare, particularly in anti-aging, skin protection, and dermatological treatments.
Khatib et al. (Tue,) studied this question.