What question did this study set out to answer?

To explore the feasibility and outcomes of extended graft replacement in patients with filamin A-related aortopathy and severe aortic regurgitation.

March 22, 2026Open Access

Extended Root and Arch Replacement for Filamin A–Related Aortopathy With Severe Aortic Regurgitation

Key Result

Filamin A-related aortopathy requires pan-aortic surveillance, and extended graft replacement may be considered in selected patients when technically and physiologically feasible.

Key Points

To explore the feasibility and outcomes of extended graft replacement in patients with filamin A-related aortopathy and severe aortic regurgitation.
Conducted pan-aortic surveillance for affected individuals.
Evaluated cases for extended graft replacement based on technical and physiological criteria.
Extended graft replacement is recommended for selected patients with FLNA aortopathy.
Patients with severe aortic regurgitation may benefit from surgical intervention.

Structured PICO

Population

Patients with Filamin A-related aortopathy and severe aortic regurgitation

Intervention

Extended root and arch replacement (extended graft replacement)

Extended graft replacement may be considered in selected patients with FLNA aortopathy when technically and physiologically feasible.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

FLNA aortopathy warrants pan-aortic surveillance. When technically and physiologically feasible, extended graft replacement may be considered in selected patients.

Read Full Paperexternally

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Journals

JACC Case Reports

Institutions

Juntendo University Hospital

References and Citations

Add This Paper to Your Research Feed

Any time a new paper drops it will be there.