What question did this study set out to answer?

The aim is to identify and characterize a new HIV-1 circulating recombinant form among a specific population in China.

March 23, 2026Virologica Sinica0 citationsOpen Access

Identification of a novel HIV-1 circulating recombinant form (CRF161₀107) from CRF01AE-C5 lineage among men who have sex with men in southwestern China

MCMin ChenYunnan Center for Disease Control And Prevention HCHuichao ChenYunnan Center for Disease Control And Prevention YMYanling MaYunnan Center for Disease Control And Prevention

Key Points

The aim is to identify and characterize a new HIV-1 circulating recombinant form among a specific population in China.
Genetic analysis to identify the novel recombinant form
Characterization of parental lineages CRF01_AE-C5 and CRF07_BC-N
Population focus on men who have sex with men in southwestern China
CRF161_0107 was identified as a novel recombinant form
It emerged around 2016 from specific parental lineages
This is the first report documenting its presence in the region, indicating HIV-1 evolution.

Abstract

• Identification of a novel HIV-1 circulating recombinant form (CRF161₀107) in Chinese men who have sex with men. • CRF161₀107 emerged around 2016, exhibiting unique CRF01AE-C5 and CRF07BC-N parental lineages. • This is the first report of a CRF derived from CRF01AE-C5 in southwestern China, suggesting viral migration. • The finding underscores the ongoing evolution of HIV-1 via recombination in key populations such as MSM.

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