Six months of continuous positive airway pressure (CPAP) therapy significantly reduced carotid intima-media thickness (p < 0.01) in patients with obstructive sleep apnea.
Does CPAP therapy reduce carotid intima-media thickness in patients with obstructive sleep apnea?
Six months of CPAP therapy significantly reduces carotid intima-media thickness, an imaging marker of atherosclerosis, in patients with obstructive sleep apnea.
Absolute Event Rate: 0% vs 0%
Background: In patients with Obstructive sleep apnea (OSA), the risks of fatal and non-fatal cardiovascular diseases and coronary artery disease are increased and measuring carotid intima-media thickness (CIMT) can assess these complications. Aim: studying the effect of OSA syndrome in the carotid artery wall thickness as an indicator to cardiovascular complications, and the effect of CPAP on these changes. Subjects 29 patients of them proved to have OSA, and 10 obese subjects with normal PSG were included as a control group. All of them had ultrasonographic assessment of CIMT. 17 patients with OSA used overnight CPAP for 6 months with remeasured CIMT. Results: 29 were diagnosed with OSA (12 severe, 9 moderate and 8 mild OSA). There was highly significant difference (p 0.05) between severe and moderate OSA. Regarding different risk factors predispose to atherosclerosis, only factors related to OSA syndrome were correlated with CIMT. There was highly significant reduction (p < 0.01) in CIMT after six months of CPAP usage. Conclusions: CIMT as a marker of atherosclerosis is significantly increased in patients with OSA and the use of CPAP in those patients is very important not only for improving sleep efficiency but also for reducing cardiovascular complications associated with OSAS.
Agha et al. (Mon,) reported a other. Six months of continuous positive airway pressure (CPAP) therapy significantly reduced carotid intima-media thickness (p < 0.01) in patients with obstructive sleep apnea.