What question did this study set out to answer?

To assess the burden of rheumatoid arthritis in middle-aged adults using global disease data from 1990 to 2021.

March 25, 2026Open Access

Rheumatoid Arthritis Burden in Middle-Aged Adults (40–59 Years): Evidence from the Global Burden of Disease 2021

Key Points

To assess the burden of rheumatoid arthritis in middle-aged adults using global disease data from 1990 to 2021.
Analysis of global burden of disease data
Evaluation of age-standardized incidence rates (ASIR)
Assessment of age-standardized prevalence rates (ASPR)
Examination of age-standardized mortality rates (ASMR)
Study of age-standardized disability rates (ASDR)
Increasing age-standardized incidence rate (ASIR) noted from 1990 to 2021
Rising age-standardized prevalence rate (ASPR) among the same demographic
Decline in age-standardized mortality rate (ASMR) observed during the period
Age-standardized disability rate (ASDR) remained relatively stable
Projections indicate that ASIR and ASPR will remain steady while ASMR and ASDR will decrease.

Abstract

Between 1990 and 2021, the RA burden among MAA was characterized by increasing ASIR and ASPR, declining ASMR, and relatively stable ASDR. Projections suggest that ASIR and ASPR will remain near recent levels, whereas ASMR and ASDR will show lower median values over time.

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Rheumatoid Arthritis Burden in Middle-Aged Adults (40–59 Years): Evidence from the Global Burden of Disease 2021

Key Points

Abstract

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