Novel multitargeted Imidazo1,2- a pyridine-1,3,4-oxadiazole hybrids: design, synthesis and biological evaluation as anti-Alzheimer’s agents

Key Points

• The aim is to develop and evaluate new chemical compounds that can effectively target Alzheimer's disease pathways.
• Design and synthesize novel imidazopyridine-oxadiazole hybrids.
• Evaluate the biological activity of these compounds against AChE and BACE1 enzymes.
• Identify promising candidates for further optimization.
• DS7 shows effective inhibition of both AChE and BACE1 activities.
• Identified DS7 as a potential lead candidate for Alzheimer's drug development.