What question did this study set out to answer?

Investigate how the MYBL2-GTSE1 axis influences the progression of laryngeal squamous cell carcinoma (LSCC) through specific molecular pathways.

March 25, 2026Open Access

The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progression by regulating PI3K/AKT-dependent glycolytic reprogramming

Investigate how the MYBL2-GTSE1 axis influences the progression of laryngeal squamous cell carcinoma (LSCC) through specific molecular pathways.
Examined the role of the MYBL2-GTSE1 axis in LSCC progression
Analyzed PI3K/AKT signaling pathways
Assessed metabolic changes related to glycolysis
MYBL2-GTSE1 axis significantly enhances LSCC progression
Inhibition of this axis affects PI3K/AKT-mediated metabolic reprogramming
Suggests potential for developing targeted therapies against LSCC

The MYBL2-GTSE1 axis promotes LSCC progression through PI3K/AKT-mediated metabolic reprogramming, representing a promising therapeutic target.