Background: Fragility fractures are a significant concern for older adults, leading to disability and healthcare use. This study evaluated the relationship between comprehensive geriatric assessment (CGA) and 10-year fracture risk in fragility clinic. Materials and Methods: This cross-sectional study of 200 individuals aged 60+ was conducted between February 2017 and October 2018. CGA included assessments of frailty (Rockwood’s Frailty Index), cognition (Hindi-Mental State Examination), mood (Geriatric Depression Scale), nutrition (Mini Nutritional Assessment), gait and balance (Timed Up and Go TUG test), sensory function, urinary incontinence, functional status (basic activities of daily living/instrumental activities of daily living), and fall history. The fracture risk assessment tool estimated 10-year fracture risk. Results: The mean age was 67.6 years, with 75% women. Polypharmacy was present in 62%, depression in 63%, and frailty in 20%. Unadjusted analyses showed that recent falls, frailty, impaired daily functioning, and abnormal TUG were linked to higher fracture risk. After adjustments, polypharmacy was associated with a lower risk of fractures (β = −1.48; 95% confidence interval CI −2.76 to −0.20; P = 0.023), possibly reflecting differences in medication classes or greater healthcare access and monitoring in this group. Vision impairment was linked to higher fracture risk (major osteoporotic fractures: β = 4.16; 95% CI 0.38–7.94 P = 0.031; hip fractures: β = 2.61; 95% CI 0.11–5.09; P = 0.040). Abnormal TUG performance showed a potential lower risk (β = −1.66; 95% CI − 3.28 to − 0.04; P = 0.045), though this may reflect test limitations. Conclusion: This study suggests that incorporating CGA-based evaluations into fracture risk assessments can identify at-risk individuals and guide preventive strategies.
Gudeti et al. (Thu,) studied this question.