Ferrocene-functionalized dithiocarbamate complexes bearing thiophene arms: synthesis, crystal structure, electrochemical characterization, in silico interaction profiling, and apoptosis induction in HeLa cells

Key Points

• The research aims to explore the synthesis and biological effects of ferrocene-functionalized dithiocarbamate complexes.
• Synthesis of ferrocene-functionalized dithiocarbamate complexes.
• Crystal structure analysis of the complexes.
• Electrochemical characterization of the complexes.
• In vitro assessment of antiproliferative effects on HeLa cells.
• Observation of apoptosis through morphological changes.
• The ferrocene DTC complex exhibits a single quasi-reversible electrochemical response.
• The Zn II –L2 complex significantly inhibits the growth of HeLa cells.
• Apoptotic bodies were observed in HeLa cells after 20 hours.