The immune system is crucial for defending the body against diseases, and immunomodulatory therapies have become promising for enhancing or suppressing immune responses. Solanum lycopersicum L. is a traditionally used herb, rich in bioactive phytoconstituents. Green synthesis of nanoparticles has become a widely explored field that offers an eco-friendly solution to the drawbacks of conventional nano-synthesis. This study explores the immunomodulatory potential of CuO nanoparticles, green-synthesised from Solanum lycopersicum L. seed extract. Preliminary screening confirmed antioxidant properties of the methanolic extract. Cytotoxicity assays revealed safety, while in vivo models demonstrated the immunomodulatory effects of both the extract and the nanoparticles. Results indicate that Solanum lycopersicum extract and its CuO nanoparticles possess antioxidant and immunomodulatory activities. The nanoparticles exhibit superior immunomodulation, suggesting therapeutic potential for immune-compromised conditions. This innovative approach addresses herbal therapy limitations, paving the way for more effective and eco-friendly immunomodulatory strategies.
Chattaraj et al. (Wed,) studied this question.