What question did this study set out to answer?

The central aim is to investigate how age and gender affect cardiac characteristics in healthy adult mice.

March 26, 2026Animal Models and Experimental Medicine0 citationsOpen Access

Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice

SWShuang WenNanjing Medical University XSXijia Shao XZXiulin Zhang

Key Result

Age and sex critically influence cardiac remodeling and baseline echocardiographic and histopathological phenotypes in healthy adult mice.

Key Points

The central aim is to investigate how age and gender affect cardiac characteristics in healthy adult mice.
Analyzed echocardiographic and histopathological data from healthy adult mice.
Established baseline metrics for cardiac parameters based on age and sex.
Developed a normative reference dataset for cardiovascular research.
Identified significant age and sex differences in cardiac remodeling metrics.
Created a comprehensive dataset that can improve reproducibility in cardiovascular studies.

Structured PICO

Population

healthy adult mice

Outcome

echocardiographic and histopathological cardiac phenotypessurrogate

Establishes a normative reference dataset for cardiac parameters in healthy adult mice to improve reproducibility and translational relevance in preclinical cardiovascular research.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

These findings underscore the critical role of age and sex in cardiac remodeling and establish a normative reference dataset for cardiac parameters in healthy adult mice. By defining robust baseline metrics, this study enhances experimental design in cardiovascular research, improving reproducibility and translational relevance of preclinical studies.

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