What question did this study set out to answer?

To describe a cobalt-catalyzed [2+2+2] cycloaddition reaction using alkynyl yndiamides and nitriles to produce novel pyridine derivatives.

March 26, 2026

Cobalt-Catalyzed 2+2+2 Cycloadditions of Alkynyl Yndiamides with Nitriles

Key Points

To describe a cobalt-catalyzed [2+2+2] cycloaddition reaction using alkynyl yndiamides and nitriles to produce novel pyridine derivatives.
Utilized cobalt as a catalyst for the cycloaddition reaction.
Conducted reactions in a non-noble metal system.
Employed a green solvent for the reaction process.
Generated 39 novel pyridine derivatives.
Achieved regioselectivity in the cycloaddition process.
Demonstrated the eco-friendliness of the reaction method.

Abstract

Herein is described a convenient cobalt-catalyzed 2+2+2 cycloaddition of alkynyl yndiamides with nitriles. This regioselective reaction provides access to 39 novel valuable 2,3-dihydro-1H-pyrrolo2,3-cpyridin-7-amine or (1,2,3,4-tetrahydro-1,7-naphthyridin-8-yl)-9H-carbazole derivatives. These highly substituted pyridines are important building blocks in medicinal chemistry. The process is eco-friendly since the cycloaddition is conducted in a green solvent with a non-noble transition metal catalyst.

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