IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide and carries a substantial risk of progression to end-stage renal disease (ESRD). In Japan, tonsillectomy combined with steroid pulse therapy (TSP) has been widely adopted as a treatment strategy to induce remission of proteinuria and hematuria. Although TSP has been reported to achieve high rates of urinary remission, a proportion of patients continue to exhibit persistent urinary abnormalities after treatment. The renal prognosis associated with these residual abnormalities remains poorly defined, and the clinicopathological characteristics of such cases have not been fully elucidated.
Aoki et al. (2026) studied this question.