What question did this study set out to answer?

To characterize pineal glioblastoma cases based on the 2021 WHO classification and assess outcome variability.

March 28, 2026

Pineal glioblastoma: a case series and updated literature review

Key Points

To characterize pineal glioblastoma cases based on the 2021 WHO classification and assess outcome variability.
Defined a cohort of pineal glioblastoma cases under the updated WHO classification.
Performed molecular and epigenetic stratifications to analyze patient outcomes.
Reviewed existing literature for a comprehensive understanding of treatment implications.
Outcomes of pineal glioblastoma cases varied significantly across the cohort.
Data supported the need for tailored prognostication strategies.
Molecular stratification indicated potential pathways for improved therapeutic decisions.

Abstract

This represents the first pineal GBM cohort defined under 2021 WHO classification. Our findings highlight the heterogeneity of outcomes, underscoring the need for molecular and epigenetic stratification to refine prognostication and therapeutic decision-making.

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