Results: Among 58 patients, 24 (41.4%)developed AKI-3.Living in Fortaleza (capital city) was associated with a lower risk (RR = 0.53; p = 0.033), while Histoplasma-like yeast visualization in peripheral blood and hepatomegaly (RR = 2.05; p = 0.029) were associated with a higher risk (RR = 2.72; p < 0.0001) of AKI-3.Patients who developed AKI-3 more often had lower body mass index (p = 0.022), and elevated Creactive protein (p = 0.009), aspartate aminotransferase (AST) (p = 0.046), direct bilirubin (p = 0.007), alkaline phosphatase (p = 0.041), LDH (p = 0.028), and Ang-2 (p = 0.031).Longer amphotericin B exposure (p = 0.032) was observed in the AKI-3 group.AKI-3 was strongly associated with intensive care unit (ICU) admission (p = 0.006), mechanical ventilation (p < 0.001), vasoactive drug use (p < 0.001), and mortality (p < 0.001). Conclusion:In PLWHA with DH, advanced AKI was frequent and strongly associated with poor outcomes.Elevated Ang-2 emerged as a potential early biomarker.These findings underscore the importance of early diagnosis, personalized treatment, and strategies to mitigate nephrotoxic exposure, ultimately enhancing clinical outcomes.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Agustina et al. (Wed,) studied this question.