Wcn26-5853 the Decline in GFR at 24 Hours Post-Nephrectomy Is Associated With Renal Function at 6 Months in Kidney Donors

Introduction: Renal donors experience a variable decrease in Glomerular Filtration Rate (GFR) in the short term and partially recover during follow-up.It remains unknown whether a greater decline in GFR during the first hours after donation is associated with a lower GFR at follow-up.Methods: Methodology: Ambispective, longitudinal, observational, and comparative study conducted at the "Dr.Miguel Silva" General Hospital.We included 61 kidney donors (January 2013 to March 2025), divided into two groups based on the delta GFR (baseline-24 hours) (Group 1: delta >40 ml/min; Group 2: delta #40 ml/min).Demographic, anthropometric, biochemical, and renal function variables were analyzed.Chi-square, Mann-Whitney U, and multiple linear regression analyses were performed to identify independent predictors of GFR at six months.Results: Table 1 shows baseline characteristics.Two differences were identified: a higher proportion of women in Group 2 (73.3% vs. 54.8%;p < 0.01) and higher baseline GFR in Group 1 113 vs. 109.2ml/min/ 1.73 m 2 ; p < 0.01.Serum creatinine at 24 hours showed a greater delta in Group 1 (p < 0.01), indicating less initial adaptation.The 24-hour GFR was lower in this group, with a more pronounced reduction compared to baseline.At six months, both baseline GFR and the 24hour delta GFR were positively associated with final GFR.In multivariate analysis (Table 2), both remained independent predictors. Conclusion:The early decline in GFR after nephrectomy is a prognostic marker of six-month renal function in living donors, independent of age, BMI, baseline GFR, creatinine, or lipid levels.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.