What question did this study set out to answer?

This study aims to determine and compare Kt/V values using Daugirdas formula and online clearance monitoring in hemodialysis patients.

March 28, 2026Kidney International Reports0 citationsOpen Access

Wcn26-2820 Clinical Profile and Causes of Mortality of Hospitalized Maintenance Hemodialysis Patients in the University of Santo Tomas Hospital: A Retrospective Study

KFKevin Raymond FregilUniversity of Santo Tomas Hospital MNMarie Stella NavarroUniversity of Santo Tomas Hospital

Key Points

This study aims to determine and compare Kt/V values using Daugirdas formula and online clearance monitoring in hemodialysis patients.
Determined Kt/V for 54 CKD patients on regular hemodialysis using Daugirdas formula and OCM.
Measured pre and post dialysis BUN, dialysis duration, ultrafiltration volume, and post dialysis weight.
Applied paired T-test, Wilcoxon signed rank test, and Pearson correlation to analyze Kt/V results.
Mean Kt/V from Daugirdas is significantly higher at 1.3982 compared to OCM at 1.1127.
Significant difference with a p-value of <0.001 and a large effect size of 1.204 between methods.
A strong positive correlation between Daugirdas and OCM Kt/V was found, with r = 0.634 and p < 0.001.

Abstract

Introduction: Dialysis adequacy is an important factor that affects the outcome of CKD patients on dialysis.Kt/V determination is a way of assessing dialysis adequacy.Daugirdas formula and online clearance monitoring (OCM) are methods that can be used to determine Kt/V.This study aimed to determine the Kt/V using Daugirdas Formula and Online Clearance Monitoring and to compare the Kt/V values using these methods Methods: Kt/V of 54 CKD patients on regular hemodialysis (HD) were determined using Daugirdas formula and OCM in 4 treatments.Pre and post HD BUN, duration of dialysis, ultrafiltration volume and post dialysis weight were used to compute for Daugirdas Kt/V.OCM Kt/V was taken from the HD machine.Paired T-test, Wilcoxon signed rank test and Pearson correlation were used to compare, analyze and determine the association of OCM and Daugirdas Kt/V.Results: Mean Kt/V from Daugirdas is 1.3982, which is significantly higher than that of OCM which is 1.1127.Mean difference was 0.2855.The t-value of 8.804 at 53 degrees of freedom yields a p-value of <0.001, indicating that this difference is highly significant.The computed effect size of 1.204 is considered very large, signifying a substantial magnitude of discrepancy between the two measurement methods.With Wilcoxon signed rank test, the test statistic of 1437.0 with a standardized z-value of 5.980 and a standard error of 0.155 yielded a p-value < 0.001, indicating a highly significant difference between the two paired measures.The effect size of 0.935 is considered very large, emphasizing that the discrepancy between Daugirdas and OCM measurements is statistically significant.The Pearson correlation analysis between the average Daugirdas and OCM Kt/V revealed a strong, positive and statistically significant relationship with an r = 0.634 and a p value < 0.001.Conclusion: There is significant difference between Kt/V values using OCM and Daugirdas.While OCM may be useful for monitoring relative changes, reliance solely on it may underestimate dialysis adequacy compared to the established Daugirdas method.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

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