CTL-NK Signature Based on Immune Gene Profiling and IHC Predicts Clinical Outcomes in Triple-Negative Breast Cancer

Key Points

• To assess the prognostic value of CTL-NK infiltration in triple-negative breast cancer (TNBC) using immune gene profiling.
• Quantitative assessment of CTL and NK cell infiltration
• Spatial analysis of immune cell distribution
• Integration of CTL-NK score into routine pathology
• CTL-NK score provides independent prognostic information in TNBC
• Integration of score could refine risk stratification
• Supports the development of personalized immunotherapy strategies