Automatic alveolar ventilation-targeted NIV mode vs polysomnographic titration of fixed pressure in naive patients with chronic respiratory failure

This study shows that iVAPS AE initiated with the 'learned target' procedure achieved similar short and long-term ventilatory efficacy to PSG manual bilevel titration. However, its higher pressure levels and lower comfort indicate that the modes are not fully equivalent. Moreover, underestimation of the AHI by the built-in software demands careful interpretation before changing ventilatory settings. Further studies are required to determine the long-term clinical relevance of these differences.