Evaluation of the QT Interval to QRS Duration Ratio as a Non-Invasive Arrhythmia Marker in Psoriatic Arthritis Patients Without Cardiovascular Comorbidities

PurposePsoriatic arthritis (PsA) is associated with increased cardiovascular (CV) events. Conduction disturbances and arrhythmias are reported, yet electrophysiological mechanisms are unclear. The index of cardio-electrophysiological balance (iCEB = QT/QRS) and its corrected form (iCEBc = QTc/QRS) are new ECG markers of ventricular depolarization-repolarization balance. This study examined whether iCEB or iCEBc differ in PsA patients without CV comorbidities.MethodsIn this retrospective case–control study, 24 PsA patients and 24 age- and sex-matched healthy controls were evaluated. Individuals with cardiovascular or metabolic disease, electrolyte or thyroid abnormalities, or cardiac medication use were excluded. Standard 12-lead ECGs were reviewed. QTc was calculated with Bazett’s formula. Group comparisons used the Mann–Whitney U test; correlations used Spearman’s coefficient.ResultsThe PsA and control groups were comparable regarding age, sex distribution, biochemical findings, and baseline ECG parameters (all p 0.05). No significant differences were observed in iCEB (4.20 vs 4.05, p = 0.284) or iCEBc (4.51 vs 4.32, p = 0.307). Within the PsA group, iCEB and iCEBc were not associated with age, duration of disease, sex, smoking status, LDL-cholesterol, or CRP (p 0.05).Discussion And ConclusionIn PsA patients without cardiovascular comorbidity, iCEB and iCEBc values were similar to those of healthy individuals, indicating preserved depolarization–repolarization balance. These results suggest that PsA alone may not increase arrhythmic risk through iCEB-related mechanisms. Larger prospective studies are required to determine whether iCEB becomes altered in patients with higher inflammatory activity or established cardiac involvement.