What question did this study set out to answer?

To investigate how PSMA PET/CT imaging reflects vascular activity in nonprostatic bone tumors, particularly giant cell tumors of bone.

April 1, 2026

Giant Cell Tumor of Bone With Intense PSMA PET/CT Avidity Simulating Bone Metastasis From Prostate Cancer

Key Points

To investigate how PSMA PET/CT imaging reflects vascular activity in nonprostatic bone tumors, particularly giant cell tumors of bone.
Case report of a 74-year-old man with a history of prostate adenocarcinoma.
Conducted PSMA PET/CT imaging that showed intense uptake in a lesion.
Performed surgery on the osteolytic lesion to prevent a fracture and obtained histopathologic analysis.
Intense PSMA uptake observed in the osteolytic lesion of the right femoral neck (SUVmax: 7.5).
Histopathology confirmed the presence of a giant cell tumor of bone.
Demonstrated that PSMA PET/CT could mislead interpretation as a metastatic lesion from prostate cancer.

Abstract

We report the case of a 74-year-old man with recurrence of prostate adenocarcinoma (PSA: 0.21 ng/mL) after radical prostatectomy. PSMA-PET/CT revealed intense uptake (SUVmax: 7.5) in an osteolytic lesion of the right femoral neck. Surgery was undertaken to prevent pathologic fracture. Histopathologic findings were consistent with a giant cell tumor of bone (GCTB). PSMA is expressed in endothelial cells of tumor neovasculature, explaining uptake in nonprostatic bone tumors. The case we report demonstrates that PSMA-PET/CT reflects vascular activity and may mimic metastasis, as prostate cancer metastases are usually sclerotic but can present as lytic lesions in the early stages.

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Giant Cell Tumor of Bone With Intense PSMA PET/CT Avidity Simulating Bone Metastasis From Prostate Cancer

Key Points

Abstract

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