What does this research mean for the field?

Plasma IL-18 levels increase over the first year of hemodialysis treatment and are associated with uremia-related markers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the changes in plasma levels of IL-18 in patients undergoing hemodialysis and its association with uremia-related markers.

April 1, 2026Open Access

IL-18 on the rise: tracking inflammatory drift in hemodialysis patients - a pilot study

Key Points

To investigate the changes in plasma levels of IL-18 in patients undergoing hemodialysis and its association with uremia-related markers.
Monitored plasma IL-18 levels in incident hemodialysis patients over one year.
Analyzed correlation with uremia-related biomarkers.
Plasma IL-18 levels significantly increased over the year of treatment.
The increase was associated with uremia-related markers, indicating a potential link.

Abstract

In this pilot study with incident HD patients, plasma IL-18 increased over one year of treatment and was associated with uremia-related markers.

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