Quinazolinone derivatives have emerged as a prominent class of heterocyclic compounds due to their diverse and significant pharmacological activities. This review aims to systematically evaluate and summarize the broad spectrum of biological properties associated with quinazolinone analogs, including their antibacterial, antimycobacterial, antifungal, antimalarial, anti-HIV, analgesic, anti-inflammatory, anticancer, anticonvulsant, muscle relaxant, trypanocidal, antileishmanial, lipid peroxidation inhibitory, genotoxic, herbicidal, hypnotic, anthelmintic, and insecticidal activities. The objective of this study is to highlight the therapeutic potential of the quinazolinone nucleus as a pharmacophore for novel drug design. A comprehensive analysis of published literature was conducted to identify recent developments in the synthesis, structure–activity relationship (SAR), and bioactivity profiles of various quinazolinone derivatives. The findings indicate that structural modifications at key positions on the quinazolinone ring can significantly enhance selectivity and potency while minimizing toxicity. This review concludes that the quinazolinone scaffold continues to be a versatile platform for the development of next-generation therapeutic agents, and it proposes specific directions for future medicinal chemistry efforts to optimize efficacy and broaden clinical applicability.
Asif et al. (Thu,) studied this question.