Background Thyroid abscesses are extremely rare due to the physiological properties of the thyroid gland; however, pre‐existing thyroid disease and immunosuppression may predispose individuals to bacterial infections, including Salmonella spp., which may present solely as a rapidly enlarging inflammatory swelling without gastrointestinal symptoms. Case Presentation We describe a case of a thyroid abscess caused by Salmonella spp. in an immunocompetent adult. The patient presented with fever, odynophagia, severe dysphagia, and a painful neck mass. Initial antimicrobial therapy and drainage were performed, identifying a quinolone‐resistant Salmonella spp. through pus culture. Recurrence was observed after 48 h, requiring a combined regimen of meropenem and vancomycin, along with a second surgical drainage that also yielded Salmonella spp. Significant clinical improvement was noted, and the patient was discharged. Discussion Localized infections caused by Salmonella spp. have been described in the thyroid and exhibit a highly variable clinical course. Complications such as capsular perforation and purulent spread into the mediastinum may arise if prompt intervention is not performed. Therefore, we emphasize the importance of considering uncommon pathogens in thyroid abscesses and advocate for a combined therapeutic approach of broad‐spectrum antimicrobials and serial drainage.
Toscano-Pacheco et al. (Thu,) studied this question.