Do triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants reduce the risk of coronary heart disease?
The clinical benefit of lowering triglyceride and LDL-C levels appears to be proportional to the absolute change in ApoB.
Triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants were associated with similar lower risk of CHD per unit difference in ApoB. Therefore, the clinical benefit of lowering triglyceride and LDL-C levels may be proportional to the absolute change in ApoB.
Ference et al. (Tue,) studied this question.
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