October 2, 2008

CD4 + Foxp3 + regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells

AWAstrid M. WestendorfUniversity of Duisburg-Essen DFDiana FleissnerNestlé (Switzerland)LGL. GroebeHelmholtz Centre for Infection Research

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Abstract

This study provides experimental evidence for a new concept in mucosal immunity: in contrast to current thinking, expansion of T(regs) can be achieved independently of local DCs through antigen-specific IEC-T cell interactions.

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Westendorf et al. (Thu,) studied this question.

synapsesocial.com/papers/69cfca26eadbfc66eb17fdef https://doi.org/https://doi.org/10.1136/gut.2008.151720

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