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April 4, 2026Open Access

Long COVID and risk of incident cardiovascular disease: a prospective cohort study using the Multimorbidity Integrated Registry Across Care Levels in Stockholm (MIRACLE-S) cohort

Key Points

To investigate the incidence of major cardiovascular events in individuals with long COVID versus controls.
Analyzed data from the Multimorbidity Integrated Registry Across Care Levels in Stockholm (MIRACLE-S) cohort.
Identified individuals aged 18-65 with diagnosed long COVID from October 2020 to January 2025.
Excluded individuals with a history of acute COVID-19 hospitalization or pre-existing cardiovascular disease.
Used Cox proportional hazards models to estimate the risk of composite cardiovascular outcomes, adjusting for various factors.
Among 1,217,693 individuals, 8,999 (0.7%) were diagnosed with long COVID.
Cumulative incidence of cardiovascular events was higher in long COVID patients (18.2% for women, 20.6% for men) compared to controls (8.4% for women, 11.1% for men).
Long COVID was linked to increased risk of composite cardiovascular outcomes: HR 2.06 for women and HR 1.33 for men.
Cardiac arrhythmia risk was significantly heightened, with HR 3.11 for women and HR 1.61 for men.
Heart failure and peripheral artery disease incidence were also elevated in women.

Abstract

Background Long COVID has emerged as a global health challenge, with increasing evidence of cardiovascular sequelae.Most previous studies have focused on hospitalised cohorts, whereas cardiovascular risk in communitymanaged long COVID cases remains less explored.We aimed to investigate the incidence of major cardiovascular events in individuals with long COVID compared to those without long COVID in a large population-based setting. MethodsMultimorbidity Integrated Registry Across Care Levels in Stockholm (MIRACLE-S) is a population-based cohort that covers all providers of healthcare for around 2.5 million residents in Stockholm County.Individuals aged 18-65 years with a physician-assigned long COVID diagnosis (ICD-10: U09.9) between October 2020 and January 2025 were identified.Exclusion criteria were hospitalisation for acute COVID-19 or pre-existing cardiovascular disease.Cox proportional hazards models estimated the effect of long COVID on a composite cardiovascular outcome (myocardial infarction, heart failure, cardiac arrhythmias, stroke, peripheral arterial disease), adjusting for demographic, lifestyle, and mental health factors.Findings Among 1,217,693 individuals, 8999 (0.7%) had long COVID diagnosis (66% women).Cumulative incidence of any cardiovascular event was higher in long COVID group (women 18.2%, men 20.6%) compared with control group (women 8.4%, men 11.1%).In a fully adjusted model, long COVID was associated with the composite cardiovascular outcome (women HR 2.06, 95% CI 1.92-2.22;men HR 1.33, 1.20-1.48),cardiac arrhythmia (women HR 3.11, 2.85-3.39;men HR 1.61, 1.41-1.85),and coronary artery disease (women HR 1.25, 1.04-1.52;men HR 1.26, 1.05-1.51).Heart failure incidence was elevated in women only (HR 1.25, 1.00-1.55),as also was peripheral artery disease (HR 1.25, 1.05-1.50).Long COVID was not associated with stroke in either sex.Interpretation Long COVID is associated with increased risk of incident cardiovascular disease, particularly cardiac arrhythmias, heart failure, and coronary artery disease.These findings underscore the need for systematic follow-up and integration of long COVID into cardiovascular risk assessment.

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Cite This Study

Lindberg et al. (Wed,) studied this question.

synapsesocial.com/papers/69d0adc2659487ece0fa43eb https://doi.org/https://doi.org/10.1016/j.eclinm.2026.103846

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