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April 4, 2026Open Access

Identification of Metabolic Biomarkers in Bone Marrow Aspirate for Diagnosis, Prognosis, and Therapeutic Monitoring in Pediatric Langerhans Cell Histiocytosis

Key Points

The research aims to discover metabolic biomarkers in bone marrow aspirate for diagnosing and monitoring LCH.
Analyzed metabolic profiles in bone marrow aspirate samples from LCH patients
Identified specific metabolites linked to LCH
Evaluated metabolites for their diagnostic and prognostic capacities
Specific metabolic alterations were identified in LCH patients
Certain metabolites indicated potential for diagnosis and prognosis
Findings suggest metabolites could assist in therapeutic monitoring

Abstract

Alterations in BMA metabolic profiles within the LCH population and in specific metabolites may provide valuable insights into LCH pathogenesis and serve as biomarkers for diagnosis, prognosis, and therapeutic response assessment.

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Cite This Study

Liu et al. (Thu,) studied this question.

synapsesocial.com/papers/69d0ae68659487ece0fa4615 https://doi.org/https://doi.org/10.3343/alm.2025.0536

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