Self-assembled influenza a neuraminidase virus-like particle vaccination confers protection against influenza B virus | Synapse
April 4, 2026
Self-assembled influenza a neuraminidase virus-like particle vaccination confers protection against influenza B virus
Key Points
The aim is to evaluate the effectiveness of the N1 VLP vaccine against influenza B virus.
Immunization of mice with N1 virus-like particles (VLPs).
Assessment of immune responses post-vaccination.
Challenge with heterologous Victoria-lineage influenza B virus.
Induction of measurable immune responses in vaccinated mice.
Significant protection against Victoria-lineage influenza B virus.
Vaccine well-tolerated with no adverse effects reported.
Abstract
These findings indicate that the N1 VLP vaccine induces measurable immune responses, confers protection against heterologous Victoria-lineage influenza B virus challenge in mice, and is well-tolerated.