What does this research mean for the field?

Universal and disease-specific quality of life questionnaires correlate significantly with clinical severity markers, including 6-minute walking distance, WHO functional class, and NT-proBNP, in patients with newly diagnosed precapillary pulmonary hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the quality of life in newly diagnosed patients with precapillary pulmonary hypertension using different questionnaires.

April 4, 2026Open Access

Assessing the quality of life with various questionnaires in newly diagnosed precapillary pulmonary hypertension

Key Result

Universal and disease-specific quality of life questionnaires correlate with 6-minute walking distance, WHO functional class, and NT-proBNP in newly diagnosed precapillary pulmonary hypertension.

Key Points

This research aims to evaluate the quality of life in newly diagnosed patients with precapillary pulmonary hypertension using different questionnaires.
Included 46 patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension.
Patients completed various quality of life questionnaires including SF-36, EQ-5D-3L, CAMPHOR, PAH-SYMPACT, and EmPHasis-10.
Correlations between quality of life measures and functional assessments were analyzed.
SF-36 scores showed low physical and psychological health values.
EQ-5D-3L indicated moderate impairments in mobility and usual activities among patients.
Positive correlations observed between SF-36 scores and six-minute walking distance; negative correlations with WHO functional class and NT-proBNP.

Structured PICO

Do universal and disease-specific quality of life questionnaires correlate with clinical and functional parameters in patients with newly diagnosed precapillary pulmonary hypertension?

Population

46 patients with newly diagnosed precapillary pulmonary hypertension (pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension), median age 42 years, 73.9% women.

Intervention

Administration of universal (SF-36, EQ-5D-3L) and pulmonary hypertension-specific (CAMPHOR, PAH-SYMPACT, EmPHasis-10) quality of life questionnaires.

Outcome

Quality of life assessment and correlation of questionnaire scales with clinical parameters (6-minute walking distance, WHO functional class, NT-proBNP, and echocardiography data).patient reported

Both universal and disease-specific quality of life questionnaires correlate well with objective clinical parameters like 6-minute walking distance and NT-proBNP, supporting their use for comprehensive functional assessment in precapillary pulmonary hypertension.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Objective. To assess QoL using various questionnaires in newly diagnosed precapillary pulmonary hypertension. Material and methods. The study included 46 patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (median age 42 years, women 73.9%). All the patients filled out QoL questionnaires: universal (SF-36, EQ-5D-3L) and special for patients with PH (CAMPHOR, PAH-SYMPACT, EmPHasis-10). Results. The SF-36 questionnaire demonstrated low values of physical and psychological components of health, as well as role-physical functioning. In EQ-5D-3L, most patients have moderate impairments in scales mobility and usual activities. There was a positive correlation of all SF-36 scales with 6-minute walking distance (6MWD) and negative correlation of most scales with WHO functional class and NT-proBNP. EQ-5D-3L, CAMPHOR, PAH-SYMPACT and EmPHasis-10 scales moderately correlated with 6MWD and NT-proBNP, and almost all scales correlated with WHO class and echocardiography data. There were strong and moderate correlations between all SF-36 scales and VAS, EQ-5D-3L and special questionnaires. Conclusion. QoL questionnaires may be used for comprehensive analysis of functional status in patients with precapillary PH.