Within the framework of nuclear medicine, as a specific and modern branch, the treatment and diagnosis of patients is carried out through the application of radioactive substances. Diagnostic procedures in nuclear medicine primarily rely on the detection of physiological and pathophysiological changes within the organism, which is achieved by using radioactively labeled compounds. Radiopharmaceuticals are radioactively labeled chemical compounds, consisting of a radioactive isotope and a carrier molecule, which has a high degree of specificity for the process under investigation. In diagnostics, 99mTc has been indisputable for decades, due to its excellent physical properties, high quality and easy availability, and the main source for obtaining it is chromatographic 99Mo/99mTc generators. Scintigraphy is a method by which we obtain a two-dimensional representation (scintigram) of the distribution of the ingested radiopharmaceutical in the body. On the other hand, single-photon emission computed tomography (SPECT) represents the circular motion of the detector around the body, along with a three-dimensional representation of the organ, which can be observed in sections, in three planes (sagittal, frontal and transverse), where any pathological process is more clearly displayed and localized more precisely.
Manjenčić et al. (Wed,) studied this question.