Reducing sedentary behavior in desk workers with untreated high blood pressure significantly lowered aldosterone (-1.5 ng/dL) and plasma renin activity (-0.2 ng/mL/h) over 3 months.
Does a sedentary behaviour reduction intervention improve heart rate variability and cardio-metabolic biomarkers in desk workers with untreated high blood pressure?
Reducing sedentary behavior in desk workers with untreated high blood pressure did not improve HRV or most cardio-metabolic biomarkers, but did significantly lower plasma renin and aldosterone levels.
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Lower sedentary behaviour (SB) has been associated with reduced cardiovascular disease and mortality. Yet, few trials have evaluated cardiovascular mechanisms of benefit. We examined the effects of a SB reduction intervention on heart rate variability (HRV) and cardio-metabolic biomarkers. We evaluated secondary outcomes in RESET-BP, a randomized clinical trial testing the effects of a 3-month SB reduction intervention on blood pressure (BP) in desk workers with untreated high BP. The intervention included health coaching, sit-stand desks, wearable activity prompters and text messages that reduced SB by increasing standing (∼1 h/day) and stepping (∼5 min/day). Resting HRV was assessed in a subset of participants. Fasting blood plasma and serum were drawn to evaluate several cardio-metabolic biomarkers, including glucose, insulin, lipids, aldosterone and plasma renin activity. Analysis of covariance models examined the effect of the intervention on outcomes. Participants with baseline and follow-up measures of HRV (n = 146) and cardio-metabolic biomarkers (n = 188) were included. No significant intervention effects were observed for any measures of HRV, glucose, insulin or lipids (all P > 0.05). Three-month changes in aldosterone (difference = -1.5 ng/dL; P = 0.0370) and plasma renin activity (difference = -0.2 ng/mL/h; P = 0.0462) were significantly lower in the intervention compared to the control condition at the 3-month follow-up. Reducing SB with mostly standing did not improve HRV or cardio-metabolic biomarkers. However, the observed intervention effects on plasma renin and aldosterone encourage future research to confirm that SB reduction suppresses the renin-angiotensin-aldosterone system activity.
Alansare et al. (Thu,) reported a other. Reducing sedentary behavior in desk workers with untreated high blood pressure significantly lowered aldosterone (-1.5 ng/dL) and plasma renin activity (-0.2 ng/mL/h) over 3 months.