To evaluate the efficacy and cardiovascular disease outcomes of intensive versus standard blood pressure control in ambulatory adults aged 75 years and older.
Randomized clinical trial (clinicaltrials.gov identifier NCT01206062) comparing an intensive systolic blood pressure target against a standard treatment target.
Evaluated participant outcomes in older adults aged 75 years and older.
Intensive systolic blood pressure reduction significantly lowers the incidence of composite fatal and nonfatal cardiovascular disease events compared with standard therapy.
Intensive management leads to a significant decrease in all-cause mortality rates among older hypertensive patients without increasing the overall rate of serious adverse events.