What question did this study set out to answer?

The aim is to assess the performance of diagnostics and clinical outcomes of pertussis in children, linked to vaccination status.

April 5, 2026Open Access

Diagnostic Performance and Clinical Outcomes of Pertussis in Hospitalized Children in Relation to Available Vaccination Status: A Retrospective Cohort Study

DLD LachowiczMedical University of Warsaw BJBarbara JastrzębskaMedical University of Warsaw EBEwa BukowskaMedical University of Warsaw

Key Points

The aim is to assess the performance of diagnostics and clinical outcomes of pertussis in children, linked to vaccination status.
Retrospective cohort design
Analysis of hospitalized children
Evaluation of vaccination history
Assessment of clinical outcomes
Identified cases of pertussis in children vaccinated within the last 5 years
Suggests possible waning immunity after vaccination
Indicates need for further studies on circulating B. pertussis strains

Abstract

The occurrence of cases several years after vaccination highlights the importance of continued surveillance to strengthen pertussis prevention strategies. Pertussis cases occurring within 5 years of wP vaccination warrant further population-based and molecular studies to evaluate potential factors such as waning immunity or antigenic changes in circulating B. pertussis strains.

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