Introduction/Objective. Acute appendicitis (AA) is the most frequent cause of emergency surgical interventions, and numerous biomarkers can be used diagnostically to differentiate patients with AA from those with pain of other etiologies, as well as to predict disease progression. The aim of this paper is to determine the accuracy of neutrophil-lymphocyte ratio-NLR, procalcitonin (PCT) and total bilirubin (TBil) in the diagnosis of complicated ?? (C???) and their comparison with the Alvarado score (AS) as well as the histopathological (HP) findings. Methods. AA was diagnosed preoperatively in 67 patients using AS. Examined parameters and AS were determined before surgery and compared postoperatively with HP findings. Depending on the HP findings, the respondents were classified into three groups: gangrenous and gangrenous-perforative appendicitis, which are classified into complicated (CoAA), phlegmonous (PhAA) and catarrhal AA (CAA). Results. The results of the univariate analysis show that ? one-unit increase in NLR increased the probability of CoAA by 20% (1.02 to 1.51, p 21?mol/l increases the probability of CoAA by 4.80 times (1.41 to 16.37, p < 0.05). ROC curve showed that PCT was the best predictor of CoAA compared to CAA/PhAA, with a cut-off of 0.56, as well as CAA in relation to PhAA/CoAA with a cut-off of 0.37. Conclusion. PCT, TBil and NLR can be used in daily clinical practice as powerful, easily available, inexpensive parameters in the diagnosis of CoAA in adults.
Dimić et al. (Thu,) studied this question.