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April 5, 2026Cancer Research0 citations

Multiomic Analysis of Distinct Signatures in HBV-, HCV-, and Non-Viral HCC

Abstract 2682: Multiomic dissection of HBV-, HCV-, and non-viral HCC reveals distinct proliferation, interferon, and metabolic signatures.

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Authors

AGAmerti GutaDODaniel O'BrienABAditya Bhagwate

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Overview

Multiomic dissection identifies unique biological pathways in HBV-, HCV-, and non-viral HCC, suggesting tailored treatments.

Key Points

  • The aim is to understand how HBV, HCV, and non-viral causes influence the molecular characteristics of hepatocellular carcinoma.
  • Analyzed TCGA-LIHC samples categorized into HBV-, HCV-, and non-viral HCC.
  • Used whole-exome sequencing and RNA sequencing to profile genomic and transcriptomic data.
  • Conducted pathway enrichment analyses and validated findings with a microarray cohort.
  • Identified distinct signatures in tumor biology based on viral etiology.
  • Non-viral HCC exhibited alterations in metabolic pathways and mitochondrial functions.
  • HCV tumors displayed enhanced interferon signaling and a high cirrhosis burden.
  • HBV-related tumors were associated with activation of cell-cycle and proliferation pathways.

Cite This Study

Guta et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd13a79560c99a0a2eb1https://doi.org/10.1158/1538-7445.am2026-2682
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