One vs. 2 vs. ≥3 TET2 mutations in chronic myelomonocytic leukemia: co-mutation patterns and prognostic relevance in the context of contemporary prognostic models including BLAST-mol and CPSS-mol

Key Points

• The research aims to evaluate the impact of different numbers of TET2 mutations on the prognosis of chronic myelomonocytic leukemia.
• Comparison of outcomes across patients with varying numbers of TET2 mutations (one, two, three or more).
• Analysis of co-mutation patterns in relation to prognostic models like BLAST-mol and CPSS-mol.
• Utilization of contemporary statistical methods to assess overall survival and disease progression.
• Patients with ≥3 TET2 mutations showed a poorer prognosis compared to those with fewer mutations.
• Co-mutation patterns significantly influenced risk stratification in chronic myelomonocytic leukemia.
• Incorporating TET2 mutations into existing prognostic models improved predictive accuracy.