Environmentally Friendly Synthesis of Polysubstituted Pyrroles in Ionic Liquid via Gold-Catalyzed Propargylic Substitution/Hydration/Amination/Cycloisomerization Sequence

Key Points

• The aim is to develop an environmentally friendly method for synthesizing polysubstituted pyrroles using ionic liquids.
• Utilized AuBr3 as a catalyst for the reaction.
• Applied a sequence of propargylic substitution, hydration, amination, and cycloisomerization.
• Carried out the reaction in ionic liquid [EMIM][NTf2].
• Reacted propargylic alcohols with 1,3-dicarbonyls and arylamines.
• Polysubstituted pyrroles were obtained in good to high yields.
• The reaction effectively combined multiple steps into one process.
• The use of ionic liquids improved the environmental profile of the synthesis.