Does exercise training prevent lipotoxic cardiomyopathy in preclinical models?
Exercise training provides cardioprotection against lipotoxic cardiomyopathy through the miR-344g-5p/HMGCS2 pathway.
Our results suggest that exercise limits lipid metabolic disorder, cardiac hypertrophy, and fibrosis and aids in the prevention of lipotoxic cardiomyopathy. Exercise-mediated cardioprotection by upregulating miR-344g-5p, which targets Hmgcs2 mRNA, prohibits HMGCS2 upregulation and thus lipotoxicity.
Li et al. (Fri,) studied this question.
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