What are the microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion?
Diabetes is associated with adverse changes in cardiac structure and microvascular perfusion, suggesting a mechanistic link between microvascular disease and cardiac dysfunction.
Patients with diabetes have increased LV mass, LV torsion, and decreased MPR. There is a significant association between decreased MPR and increased LV torsion suggesting a possible mechanistic link between microvascular disease and cardiac dysfunction in diabetes.
Larghat et al. (2014) studied this question.