Why the study?
Major depressive disorder is phenotypically associated with cardiovascular diseases, but the mechanisms underlying these relationships in the context of shared genetic variations remain to be investigated.
Does genetic liability to major depressive disorder causally increase the risk of cardiovascular diseases?
Comparison
Major depressive disorder vs seven cardiovascular outcomes
Design
Polygenic overlap and Mendelian randomization study
Authors
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MDD genetic liability may warrant closer CVD risk monitoring; supports causality while extending shared loci and novel gene targets for research.
Does genetic liability to major depressive disorder causally increase the risk of cardiovascular diseases?
This study provides genetic evidence that major depressive disorder shares pleiotropic risk loci with cardiovascular diseases and causally increases the risk of coronary artery disease and stroke.
Zhang et al. (2021) studied this question.