Does the withdrawal of digoxin carry risks for patients with chronic heart failure and impaired systolic function who are clinically stable on digoxin and ACE inhibitors?
Withdrawing digoxin from stable heart failure patients with impaired systolic function on ACE inhibitors poses considerable clinical risks.
These findings indicate that the withdrawal of digoxin carries considerable risks for patients with chronic heart failure and impaired systolic function who have remained clinically stable while receiving digoxin and angiotensin-converting-enzyme inhibitors.
Packer et al. (1993) studied this question.