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January 11, 2017New England Journal of Medicine3,275 citationsOpen Access

Phase 3 Trial of 177 Lu-Dotatate for Midgut Neuroendocrine Tumors

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JSJonathan StrosbergGEGhassan El‐HaddadEWEdward M. Wolin

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Abstract

Treatment with 177Lu-Dotatate resulted in markedly longer progression-free survival and a significantly higher response rate than high-dose octreotide LAR among patients with advanced midgut neuroendocrine tumors. Preliminary evidence of an overall survival benefit was seen in an interim analysis; confirmation will be required in the planned final analysis. Clinically significant myelosuppression occurred in less than 10% of patients in the 177Lu-Dotatate group. (Funded by Advanced Accelerator Applications; NETTER-1 ClinicalTrials.gov number, NCT01578239 ; EudraCT number 2011-005049-11 .).

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Strosberg et al. (2017) studied this question.

synapsesocial.com/papers/69d5768ee1904fea15e911f0https://doi.org/10.1056/nejmoa1607427
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