Aquaporin 9 regulates acetaldehyde uptake, alcohol‐induced liver injury, and drinking behavior

Key Points

• This research aims to investigate the role of aquaporin 9 in acetaldehyde uptake and its effects on alcohol-induced liver injury and drinking behavior.
• Examined the role of aquaporin 9 in hepatocyte acetaldehyde uptake.
• Analyzed its effect on alcohol liver disease progression.
• Assessed drinking behavior influenced by aquaporin 9 activities.
• Aquaporin 9 facilitates increased acetaldehyde uptake in liver cells.
• Enhanced uptake contributes to the worsening of alcohol liver disease.
• Changes in drinking behavior were linked to aquaporin 9 activity.