Does adrenergic receptor blockade reverse right ventricular remodeling and dysfunction in pulmonary hypertensive rats?
Adrenergic receptor blockade reverses right ventricular remodeling and dysfunction in a rat model of pulmonary hypertension, suggesting a potential therapeutic avenue that requires clinical trial validation in humans.
Adrenergic receptor blockade reverses RV remodeling and improves RV function in experimental pulmonary hypertension. Beta-adrenergic receptor blockers are not recommended in humans with PAH before their safety and efficacy are assessed in well-designed clinical trials.
Bogaard et al. (Thu,) studied this question.