Elevated Interleukin‐6 Levels in Socioeconomically Disadvantaged Children With Borderline Subclinical Rheumatic Heart Disease in São Paulo, Brazil: A Prospective Cohort Study Highlighting Early Detection and Treatment Opportunities

Key Points

• The aim is to explore the relationship between interleukin-6 levels and borderline subclinical rheumatic heart disease in disadvantaged children.
• Conducted a prospective cohort study in São Paulo, Brazil.
• Monitored interleukin-6 levels over at least two years.
• Evaluated potential biomarkers for early detection and treatment opportunities.
• Observed sustained elevated levels of interleukin-6 in affected children.
• Identified interleukin-6 as a potential early biomarker for borderline subclinical rheumatic heart disease.
• Highlighted the importance of early therapeutic interventions to prevent disease progression.