Single-Cell and Bulk Transcriptomic Integration Reveals a Stemness-Related Astrocyte Subpopulation for Prognostic Risk Stratification in Glioblastoma

Key Points

• The study aims to identify a gene signature associated with stemness that can help stratify glioblastoma risk.
• Developed a four-gene signature related to stemness.
• Conducted transcriptomic integration at single-cell and bulk levels.
• Analyzed tumor microenvironment characteristics.
• Identified an immunosuppressive microenvironment in high-risk glioblastoma tumors.
• Provided a prognostic tool for risk stratification using the four-gene signature.

Abstract