A Study of the Effect of Varying Time Intervals between Fentanyl and Propofol on Propofol Requirement for Induction of General Anesthesia: A Randomized Prospective Controlled Study | Synapse
April 10, 2026
A Study of the Effect of Varying Time Intervals between Fentanyl and Propofol on Propofol Requirement for Induction of General Anesthesia: A Randomized Prospective Controlled Study
Key Points
The aim is to investigate how varying time intervals between fentanyl and propofol affect the dose of propofol needed for general anesthesia induction.
Randomized controlled study design
Administration of propofol 5 minutes after fentanyl
Assessment of induction dose requirements
Evaluation of haemodynamic parameters during induction and intubation
Significant reduction in propofol induction dose when given after fentanyl
Improved haemodynamic stability observed during induction and intubation
Abstract
Administering propofol 5 min after fentanyl significantly reduces induction dose requirements and improves haemodynamic stability during induction and intubation.