Enhanced biophysical, electrochemical and computational recognition of cancer-relevant G-quadruplex DNA by ferrocenyl curcumin Schiff base motifs | Synapse
April 10, 2026
Enhanced biophysical, electrochemical and computational recognition of cancer-relevant G-quadruplex DNA by ferrocenyl curcumin Schiff base motifs
Key Points
Explore the enhanced recognition of G-quadruplex DNA structures important for gene regulation and cancer.
Investigated biophysical characteristics of G-quadruplex DNA.
Utilized electrochemical techniques for detection.
Applied computational analyses for interaction modeling.
Improved binding affinity of ferrocenyl curcumin to G-quadruplex DNA.
Significant electrochemical signal changes observed with target DNA.
Computational models confirm interaction stability and specificity.
Abstract
G-quadruplex DNA structures located in promoter and telomeric regions play critical roles in gene regulation and cancer progression, making them attractive targets for small-molecule intervention.