Breakpoints in Alzheimer's disease biomarkers and cognition across the aging spectrum: The Mayo Clinic Study of Aging

Key Points

• To identify breakpoints in Alzheimer's disease biomarkers and cognition throughout the aging process.
• Analyzed data from the Mayo Clinic Study of Aging
• Focused on late midlife as a critical period
• Investigated the relationship between biomarkers and cognitive function
• Breakpoints for biomarkers cluster near late midlife
• Significant implications for screening strategies
• Identified critical windows for monitoring cognitive health